Methadone and its effect on QTc prolongation
نویسندگان
چکیده
منابع مشابه
qtc prolongation in acute methadone poisoning
background : methadone is considered as a good choice for maintenance treatment program (mmtp) in opioid addicted individuals. qt interval prolongation was reported previously in methadone chronic usersespecially in high dose prescription. qt-interval prolongation predisposes patients to lethal dysrhythmia. this is a report of corrected qt(qtc) prolongation due to acute methadone poisoning. to ...
متن کاملQTc Prolongation in Veterans With Heroin Dependence on Methadone Maintenance Treatment
BACKGROUND QTc prolongation and Torsade de Ppointes have been reported in patients on methadone maintenance. OBJECTIVES In this study, QTc was compared before and after the veteran (n = 49) was on a stable dosage of methadone for 8.72 ± 4.50 years to treat heroin dependence. Risk factors were correlated with the QTc once the veteran was on a stable dose of methadone. Differences in the clinic...
متن کاملParoxetine‐induced QTc prolongation
There have been only two previous reports of paroxetine-induced corrected QT (QTc) prolongation on electrocardiogram (ECG). Here, we report a 43-year-old woman with QTc prolongation (476 ms). She had taken 50 mg of paroxetine for 17 days. Three days after discontinuation of paroxetine, QTc returned to within the normal limits (396 ms). Paroxetine blocks the human ether-a-go-go-related gene (HER...
متن کاملRetrospective analysis of low-dose methadone and QTc prolongation in chronic pain patients
BACKGROUND Methadone is a synthetic opioid that is widely used for the treatment of chronic pain. The association between methadone treatment and QT interval prolongation or which can lead to torsades de pointes has been confirmed with larger studies on high dose methadone. The aim of this study was to determine the effect of methadone on the QTc interval in patients, whether the daily dose of ...
متن کاملqtc prolongation in veterans with heroin dependence on methadone maintenance treatment
results the mean qtc at baseline (pre-methadone) was 426 ± 34 msec and after being on methadone for an average of 8.72 ± 4.50 years was significantly higher at 450 ± 35 msec. no significant relationships were found between qtc prolongation and risk factors except for calcium. the methadone dosage was significantly higher in veterans with a qtc change above the mean change of ≥ 24 msec (88.48 ± ...
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ژورنال
عنوان ژورنال: Irish Journal of Psychological Medicine
سال: 2009
ISSN: 0790-9667,2051-6967
DOI: 10.1017/s0790966700017961